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Th thaputic ct ACTOS in combination with insulin was obsvd in patints gadlss th insulin dos.

ACTOS tablts a a thiazolidindion and an agonist poxisom poliato-activatd cpt(PPA) gamma that contains an oal antidiabtic mdication: pioglitazon.

ACTOS may caus dcass in hmoglobin and hmatocit. In placbo-contolld monothapy tials, man hmoglobin valus dclind by 2% t4% in patints tatd with ACTOS compad with a man chang in hmoglobin -1% t+1% in placbo-tatd patints. Ths changs pimaily occud within th ist 4 t12 wks thapy and maind lativly constant that. Ths changs may b latd tincasd plasma volum associatd with ACTOS thapy and a not likly tb associatd with any clinically signiicant hmatologic cts.

Know th mdicins you tak. Kp a list you mdicins and show it tyou doctand phamacist byou stat a nw mdicin. Thy will tll you i it is okay ttak ACTOS with oth mdicins.

ACTOS xts its antihypglycmic ct only in th psnc ndognous insulin. ACTOS should not b usd ttat typ 1 diabts diabtic ktoacidosis, as it would not b ctiv in ths sttings.

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in 1999, the fda requested takeda pharmaceuticals to conduct a marketing study on the safety of actos; however, the company allegedly delayed this important report and it was later discovered that patients taking actos for more than one year had a higher chance of contracting bladder cancer and other serious side effects.

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